Endep (Desipramine) – What It Is and How It Works

If you’ve seen a prescription for Endep and wonder what it does, you’re in the right place. Endep is the brand name for desipramine, a tricyclic antidepressant (TCA) that helps lift mood by increasing the levels of norepinephrine and serotonin in the brain. Doctors usually write it for major depressive disorder, but it can also help with certain anxiety‑related conditions.

Typical Dosage and How to Take It

The starting dose is usually low – 25 mg once a day – to let your body get used to the medication. Your doctor may raise the dose gradually, often to 100 mg daily, depending on how you respond. Most people take Endep in the morning or early afternoon because it can make you feel a bit drowsy or, conversely, more energetic. Swallow the tablet whole with a full glass of water; don’t crush or chew it.

If you miss a dose, take it as soon as you remember—unless it’s almost time for your next dose. In that case, skip the missed one and resume your regular schedule. Never double up; that can raise the risk of side effects.

Common Side Effects and When to Call the Doctor

Like any medication, Endep comes with a set of side effects. The most frequent ones include dry mouth, constipation, blurry vision, and a mild increase in heart rate. Some people feel a bit dizzy when they stand up quickly—this is called orthostatic hypotension.

Serious but rare reactions include irregular heartbeat, severe low blood pressure, or signs of a mood switch toward mania. If you notice a fast or irregular pulse, fainting, or sudden mood changes, contact your healthcare provider right away.

Sexual side effects—like decreased libido or difficulty achieving orgasm—are also reported. Talk openly with your doctor if this becomes an issue; they can adjust the dose or suggest an alternative.

Safety Tips and Interactions

Before you start Endep, tell your doctor about any other meds you’re taking, especially other antidepressants, antihistamines, or blood pressure drugs. Mixing Endep with certain medications can raise the risk of serotonin syndrome, a potentially dangerous condition marked by agitation, rapid heartbeat, and high fever.

Avoid alcohol while on Endep; the combination can worsen drowsiness and increase the chance of liver strain. If you’re pregnant, planning to become pregnant, or breastfeeding, discuss the risks with your doctor—TCAs can cross the placenta and appear in breast milk.

Keep regular appointments for blood checks, especially during the first few weeks. Your doctor will monitor liver function, electrolytes, and heart rhythm to catch any early warning signs.

What to Expect When Stopping Endep

Never stop taking Endep abruptly. Your brain has adapted to its presence, and a sudden halt can trigger withdrawal symptoms like nausea, headache, and a rebound of depression. If you and your doctor decide it’s time to quit, the dose will be tapered down slowly over weeks.

Overall, Endep can be an effective tool for managing depression when used correctly. By following dosage guidelines, staying aware of side effects, and keeping an open line with your healthcare team, you can maximize benefits while minimizing risks.